The PSA-doubling time at relapse is one of the relevant factors for predicting the survival period after PSA relapse. Final PSA-doubling time was not correlated with the survival period after PSA relapse. The median overall survival time for patients with a PSADT < or 8 months was 61.8 months (p 0. The median overall survival time for patients with a PSADT >8 months was not reached in this study. The PSA-doubling time of 2 months or less at relapse was suggestive of a poor outcome. The estimated 6-year overall survival rate after PSA failure was 79.1 for men with a PSADT >8 months and 29.7 for men with a PSADT < or 8 months. The period between PSA relapse and death was related with PSA-doubling time at relapse, nadir PSA and the period between the start of treatment and PSA relapse. To calculate PSA-doubling time, assay of PSA was carried out every 3 months or less.

Other authors have clearly demonstrated that PSA doubling time adds information to other available predictors. The present study was aimed to establish the predicting factors influencing the survival period of patients at prostate-specific antigen (PSA) relapse (entering the hormone refractory state).įifty-six patients with prostate cancer and bone metastasis, who were treated during the entire disease period at the same hospital and died were studied. The risk of prostate cancer death within five-years of relapse was 50 for patients with a PSA doubling time of 12 months or less compared to 10 for patients with a doubling time greater than 12 months7. After relapse, the disease progresses in various courses. Benson, MD, at the 32nd Winter Urologic Forum State-of-the-Art in Urology January 25-29, 2008 Vail, Colorado, USA most men who have failed a local, primary therapy and then experience a rising PSA will. According to a recent presentation by Mitchell C. Most of the metastatic diseases initially respond to maximum androgen blockade, but then relapse and lose response, and finally die. PSA Levels & PSA Velocity (Doubling Time) Is Predictive of Your Survival Time. The PSA doubling time Whether the recurrence occurred within three years or after three years A recurrence that occurs within three years reduces survival rates by anywhere from 15 to 20and even more, if the doubling time is short.

Psa doubling time survival rate